Issue 80, 2012
From the journal:

Chemical Communications

Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX†

Brett Waybrant,a   Timothy R. Pearce,b   Ping Wang,c   Srinand Sreevatsanc  and  Efrosini Kokkoli*a  

* Corresponding authors

a Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, USA
E-mail: kokkoli@umn.edu

b Department of Biomedical Engineering, University of Minnesota, Minneapolis, USA

c Veterinary Population Medicine, University of Minnesota, Saint Paul, USA

Abstract

Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.

Graphical abstract: Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX

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Article information

DOI
https://doi.org/10.1039/C2CC34217K
Article type
Communication
Submitted
13 Jun 2012
Accepted
19 Aug 2012
First published
31 Aug 2012

Chem. Commun., 2012,48, 10043-10045

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Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX

B. Waybrant, T. R. Pearce, P. Wang, S. Sreevatsan and E. Kokkoli, Chem. Commun., 2012, 48, 10043 DOI: 10.1039/C2CC34217K

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