Issue 68, 2012
From the journal:

Chemical Communications

Silica-based gene reverse transfection: an upright nanosheet network for promoted DNA delivery to cells†

Qingmin Ji,*a   Tomohiko Yamazaki,b   Nobutaka Hanagata,*b   Michael V. Lee,a   Jonathan P. Hillac  and  Katsuhiko Ariga*ac  

* Corresponding authors

a World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
E-mail: ARIGA.Katsuhiko@nims.go.jp, JI.Qingmin@nims.go.jp

b Interdisciplinary Laboratory for Nanoscale Science and Technology, National Institute for Materials Science (NIMS), 1-2-1 Sengen, Tsukuba, Japan
E-mail: HANAGATA.Nobutaka@nims.go.jp

c JST, CREST, 1-1 Namiki, Ibaraki 305-0044, Tsukuba, Japan

Abstract

A method for substrate-mediated reverse gene transfection was developed using a silica film composed of an upright-sheet network. The silica film with a dense upright-sheet network shows approximately double higher transgene expression efficiency than that of solution-based transfection.

Graphical abstract: Silica-based gene reverse transfection: an upright nanosheet network for promoted DNA delivery to cells

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Article information

DOI
https://doi.org/10.1039/C2CC34289H
Article type
Communication
Submitted
15 Jun 2012
Accepted
06 Jul 2012
First published
06 Jul 2012

Chem. Commun., 2012,48, 8496-8498

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Silica-based gene reverse transfection: an upright nanosheet network for promoted DNA delivery to cells

Q. Ji, T. Yamazaki, N. Hanagata, M. V. Lee, J. P. Hill and K. Ariga, Chem. Commun., 2012, 48, 8496 DOI: 10.1039/C2CC34289H

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