Issue 74, 2012
From the journal:

Chemical Communications

Rhodium acetate/base-catalyzed N-silylation of indole derivatives with hydrosilanes†

Shintaro Itagaki,a   Keigo Kamata,a   Kazuya Yamaguchia  and  Noritaka Mizuno*a  

* Corresponding authors

a Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
E-mail: tmizuno@mail.ecc.u-tokyo.ac.jp
Fax: +81-3-5841-7220
Tel: +81-3-5841-7272

Abstract

In the presence of Rh2(OAc)4 (OAc = acetate) and TBA2WO4 (TBA = tetra-n-butylammonium), the N-silylation of indole derivatives with hydrosilanes efficiently proceeded to give the corresponding N-silylated indoles in high yields. Pyrrole and carbazole were also N-silylated with the combined catalysts.

Graphical abstract: Rhodium acetate/base-catalyzed N-silylation of indole derivatives with hydrosilanes

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Article information

DOI
https://doi.org/10.1039/C2CC34381A
Article type
Communication
Submitted
19 Jun 2012
Accepted
26 Jul 2012
First published
26 Jul 2012

Chem. Commun., 2012,48, 9269-9271

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Rhodium acetate/base-catalyzed N-silylation of indole derivatives with hydrosilanes

S. Itagaki, K. Kamata, K. Yamaguchi and N. Mizuno, Chem. Commun., 2012, 48, 9269 DOI: 10.1039/C2CC34381A

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