An interrupted PET coupled TBET process for the design of a specific receptor for Hg2+ and its intracellular detection in MCF7 cells

Sukdeb Saha; Prasenjit Mahato; Mithu Baidya; Sudip K. Ghosh; Amitava Das

doi:10.1039/C2CC34490D

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An interrupted PET coupled TBET process for the design of a specific receptor for Hg²⁺ and its intracellular detection in MCF7 cells†

Sukdeb Saha,^a Prasenjit Mahato,^a Mithu Baidya,^b Sudip K. Ghosh*^b and Amitava Das*^a

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* Corresponding authors

^a CSIR-Central Salt and Marine Chemicals Research Institute, Bhavnagar - 364002, Gujarat, India
E-mail: amitava@csmcri.org

^b Department of Biotechnology, Indian Institute of Technology, Kharagpur, West Bengal - 721302, India

Abstract

A new coumarin–rhodamine conjugate constitutes a unique example of the interrupted PET coupled TBET response for developing an imaging reagent for determining the intracellular distribution of Hg²⁺ in MCF7 cells exposed to [Hg²⁺] as low as 2 ppb.

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Article information

DOI: https://doi.org/10.1039/C2CC34490D
Article type: Communication
Submitted: 22 Jun 2012
Accepted: 26 Jul 2012
First published: 26 Jul 2012

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Chem. Commun., 2012,48, 9293-9295

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An interrupted PET coupled TBET process for the design of a specific receptor for Hg²⁺ and its intracellular detection in MCF7 cells

S. Saha, P. Mahato, M. Baidya, S. K. Ghosh and A. Das, Chem. Commun., 2012, 48, 9293 DOI: 10.1039/C2CC34490D

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