Issue 80, 2012
From the journal:

Chemical Communications

Rational engineering of Candida antarctica lipase B for selective monoacylation of diols†

Anders Hamberg,a   Steffen Maurerb  and  Karl Hult*a  

* Corresponding authors

a School of Biotechnology, Department of Biochemistry, Royal Institute of Technology (KTH), AlbaNova, SE-106 91 Stockholm, Sweden
E-mail: kalle@biotech.kth.se
Fax: +46 8 5537 8468
Tel: +46 8 5537 8364

b BASF SE, GVF/E-A030, 67056 Ludvigshafen, Germany
E-mail: steffen.maurer@basf.com
Fax: +49 621 60 52808
Tel: +49 621 60 43694

Abstract

The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.

Graphical abstract: Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC34684B
Article type
Communication
Submitted
30 Jun 2012
Accepted
17 Aug 2012
First published
22 Aug 2012

Chem. Commun., 2012,48, 10013-10015

Permissions

Request permissions

Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

A. Hamberg, S. Maurer and K. Hult, Chem. Commun., 2012, 48, 10013 DOI: 10.1039/C2CC34684B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements