Heterogeneous asymmetric Henry–Michael one-pot reaction synergically catalyzed by grafted chiral bases and inherent achiral hydroxyls on mesoporous silica surface

Abstract

Highly efficient and enantioselective asymmetric Henry–Michael one-pot reaction has been achieved on bifunctional heterogeneous catalysts with inherent achiral hydroxyls as acidic sites and immobilized chiral amines as basic sites. Final products were afforded in yields of up to 85% and ee of 99%.