Issue 79, 2012
From the journal:

Chemical Communications

Graphene oxide–photosensitizer conjugate as a redox-responsive theranostic agent†

Youngnam Choab  and  Yongdoo Choi*a  

* Corresponding authors

a Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Korea
E-mail: ydchoi@ncc.re.kr
Fax: +82 31-920-2529
Tel: +82 31-920-2512

b Center for Paralysis Research, Dept. of Basic Medical Science, Purdue University, USA

Abstract

A nano-sized graphene oxide–photosensitizer conjugate with a redox-responsive cleavable disulfide linker is non-fluorescent and non-phototoxic, even upon light irradiation. It becomes highly fluorescent and phototoxic inside cancer cells, where glutathione is used as an initiator for activating the photosensitizer.

Graphical abstract: Graphene oxide–photosensitizer conjugate as a redox-responsive theranostic agent

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Article information

DOI
https://doi.org/10.1039/C2CC35197H
Article type
Communication
Submitted
19 Jul 2012
Accepted
17 Aug 2012
First published
17 Aug 2012

Chem. Commun., 2012,48, 9912-9914

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Graphene oxide–photosensitizer conjugate as a redox-responsive theranostic agent

Y. Cho and Y. Choi, Chem. Commun., 2012, 48, 9912 DOI: 10.1039/C2CC35197H

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