A system capable of performing both DNA-templated chemical reactions and detection of bond formations is reported. Photocleavable DNA templates direct reactions. Products from bond-forming events re-ligate original templates, amplifiable by PCR, therefore distinguishing bond formation from background. This system provides a novel approach for discovering potential new chemical reactions.
Y. Li, M. Zhang, C. Zhang and X. Li, Chem. Commun., 2012, 48, 9513 DOI: 10.1039/C2CC35230C
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