Issue 83, 2012
From the journal:

Chemical Communications

Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors†

Allimuthu T. Dharmaraja,a   Mallika Alvala,b   Dharmarajan Sriram,b   Perumal Yogeeswarib  and  Harinath Chakrapani*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Pune 411 008, Maharashtra, India
E-mail: harinath@iiserpune.ac.in
Fax: +91-20-2589-9790
Tel: +91-20-2590-8090

b Department of Pharmacy, Birla Institute of Technology & Science Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad 500 078, India

Abstract

Here, we report 5-hydroxy-1,2,3,4,4a,9a-hexahydro-1,4-ethano-9,10-anthraquinone (13), a small molecule generating reactive oxygen species (ROS) in pH 7.4 buffer under ambient aerobic conditions that has selective and potent Mycobacterium tuberculosis growth inhibitory activity.

Graphical abstract: Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC35343A
Article type
Communication
Submitted
24 Jul 2012
Accepted
20 Aug 2012
First published
21 Aug 2012

Chem. Commun., 2012,48, 10325-10327

Permissions

Request permissions

Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

A. T. Dharmaraja, M. Alvala, D. Sriram, P. Yogeeswari and H. Chakrapani, Chem. Commun., 2012, 48, 10325 DOI: 10.1039/C2CC35343A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements