Issue 90, 2012
From the journal:

Chemical Communications

Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptidevia the substitution of lysine with arginine†

Ikuhiko Nakase,*a   Shinya Okumura,a   Sayaka Katayama,a   Hisaaki Hirose,a   Sílvia Pujals,a   Hirofumi Yamaguchi,b   Satoko Arakawa,b   Shigeomi Shimizub  and  Shiroh Futaki*a  

* Corresponding authors

a Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
E-mail: nakase@scl.kyoto-u.ac.jp, futaki@scl.kyoto-u.ac.jp
Fax: +81-774-32-3038
Tel: +81-774-32-3038

b Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan

Abstract

Simple substitution of D-lysine with D-arginine in antimicrobial peptide (RLA) considerably improved its membrane permeability and increased mitochondrial accumulation. The potential use of RLA in preventing apoptotic cell death is also demonstrated through delivery of the Bcl-xL BH4 domain peptide.

Graphical abstract: Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine

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Article information

DOI
https://doi.org/10.1039/C2CC35872G
Article type
Communication
Submitted
14 Aug 2012
Accepted
25 Sep 2012
First published
26 Sep 2012

Chem. Commun., 2012,48, 11097-11099

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Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine

I. Nakase, S. Okumura, S. Katayama, H. Hirose, S. Pujals, H. Yamaguchi, S. Arakawa, S. Shimizu and S. Futaki, Chem. Commun., 2012, 48, 11097 DOI: 10.1039/C2CC35872G

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