Issue 89, 2012

Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

Abstract

A novel and efficient double-carbonylation of indoles with primary or secondary amines to yield indole-3-α-ketoamides has been developed and bioactive molecules could be one-pot synthesized using the current methodology, which could also be selectively switched to mono-carbonylation to afford indole-3-amides only by a slight modification of reaction conditions.

Graphical abstract: Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug 2012
Accepted
23 Sep 2012
First published
25 Sep 2012

Chem. Commun., 2012,48, 11023-11025

Palladium-catalyzed mono- and double-carbonylation of indoles with amines controllably leading to amides and α-ketoamides

Q. Xing, L. Shi, R. Lang, C. Xia and F. Li, Chem. Commun., 2012, 48, 11023 DOI: 10.1039/C2CC36341K

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