Issue 96, 2012
From the journal:

Chemical Communications

Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery†‡

Thomas-Xavier Métro,*a   Julien Bonnamour,a   Thomas Reidon,a   Jordi Sarpoulet,a   Jean Martineza  and  Frédéric Lamaty*a  

* Corresponding authors

a Institut des Biomolécules Max Mousseron, UMR 5247 Université Montpellier 1 et Université Montpellier 2-CNRS, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France
E-mail: txmetro@um2.fr, frederic.lamaty@univ-montp2.fr

Abstract

The synthesis of various amides has been realised avoiding the use of any organic solvent from activation of carboxylic acids with CDI to isolation of the amides. Mechanochemistry was the key point of the process allowing rapid formation of the amide bond and efficient water-based purification of the final products.

Graphical abstract: Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

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Article information

DOI
https://doi.org/10.1039/C2CC36352F
Article type
Communication
Submitted
31 Aug 2012
Accepted
08 Oct 2012
First published
29 Oct 2012

Chem. Commun., 2012,48, 11781-11783

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Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery

T. Métro, J. Bonnamour, T. Reidon, J. Sarpoulet, J. Martinez and F. Lamaty, Chem. Commun., 2012, 48, 11781 DOI: 10.1039/C2CC36352F

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