Issue 92, 2012

Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

Abstract

Invasive binding event of PNA into DNA duplex was clearly observed both by atomic force microscope (AFM) imaging and electrophoretic mobility shift assay (EMSA) with the aid of nanomechanical DNA origami devices as ‘single-molecule’ visual probes, showing their potential as universal platform for the analysis of PNA invasion.

Graphical abstract: Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Chem. Commun., 2012,48, 11361-11363

Clear-cut observation of PNA invasion using nanomechanical DNA origami devices

T. Yamazaki, Y. Aiba, K. Yasuda, Y. Sakai, Y. Yamanaka, A. Kuzuya, Y. Ohya and M. Komiyama, Chem. Commun., 2012, 48, 11361 DOI: 10.1039/C2CC36358E

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