Issue 93, 2012

Mercury–thymine interaction with a chair type G-quadruplex architecture

Abstract

The T–Hg–T bond was utilized to cross-link two lateral loops of chair-type G-quadruplex DNA (G4-DNA) structures. Two out of five cross-linking geometries are able to increase the melting temperature and simultaneously reduce the polymorphism of the G4-DNA conformations.

Graphical abstract: Mercury–thymine interaction with a chair type G-quadruplex architecture

Supplementary files

Article information

Article type
Communication
Submitted
05 Sep 2012
Accepted
11 Oct 2012
First published
12 Oct 2012

Chem. Commun., 2012,48, 11464-11466

Mercury–thymine interaction with a chair type G-quadruplex architecture

N. M. Smith, S. Amrane, F. Rosu, V. Gabelica and J. Mergny, Chem. Commun., 2012, 48, 11464 DOI: 10.1039/C2CC36481F

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