Issue 2, 2012

A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat

Abstract

A new kinetically stable polymorph of Vorinostat has been discovered as a result of a polymorph screening, however an impurity is always formed in its preparation by crystallization. The interaction of Vorinostat with ammonia yields a new cocrystal which transforms easily through thermal desorption into the new polymorph with a high degree of purity.

Graphical abstract: A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat

Supplementary files

Article information

Article type
Communication
Submitted
27 Jun 2011
Accepted
09 Nov 2011
First published
21 Nov 2011

CrystEngComm, 2012,14, 362-365

A cocrystal is the key intermediates for the production of a new polymorph of Vorinostat

C. Puigjaner, R. Barbas, A. Portell, I. Valverde, X. Vila, X. Alcobé, M. Font-Bardia and R. Prohens, CrystEngComm, 2012, 14, 362 DOI: 10.1039/C1CE05799E

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