Issue 7, 2012
From the journal:

CrystEngComm

Separation of impurities from solution by selective co-crystal formation†

Kay Huai-Ying Hsi,a   Keith Chadwick,a   Amanda Fried,a   Meghan Kennya  and  Allan S. Myersona  

a Novartis-MIT Center for Continuous Manufacturing and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-502b, Cambridge, Massachusetts, United States

Abstract

The potential use of selective co-crystal formation as a means to remove an impurity from a solution is demonstrated using ibuprofen and ketoprofen as a model system. A strategy for selecting the optimal co-former, co-former concentration, and the solvent for the separation process is discussed.

Graphical abstract: Separation of impurities from solution by selective co-crystal formation

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Article information

DOI
https://doi.org/10.1039/C1CE06358H
Article type
Communication
Submitted
13 Oct 2011
Accepted
09 Nov 2011
First published
16 Nov 2011

CrystEngComm, 2012,14, 2386-2388

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Separation of impurities from solution by selective co-crystal formation

K. H. Hsi, K. Chadwick, A. Fried, M. Kenny and A. S. Myerson, CrystEngComm, 2012, 14, 2386 DOI: 10.1039/C1CE06358H

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