Co-crystals of caffeine and piracetam with 4-hydroxybenzoic acid: Unravelling the hidden hydrates of 1 : 1 co-crystals

Srinivasulu Aitipamula; Pui Shan Chow; Reginald B. H. Tan

doi:10.1039/C2CE25080B

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Co-crystals of caffeine and piracetam with 4-hydroxybenzoic acid: Unravelling the hidden hydrates of 1 : 1 co-crystals†

Srinivasulu Aitipamula,*^a Pui Shan Chow^a and Reginald B. H. Tan*^ab

Author affiliations

* Corresponding authors

^a Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1, Pesek Road, Jurong Island, Singapore
E-mail: srinivasulu_aitipamula@ices.a-star.edu.sg

^b Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore
E-mail: reginald_tan@ices.a-star.edu.sg

Abstract

Attempts to prepare 1 : 1 co-crystals of caffeine and piracetam with 4-hydroxybenzoic acid have led to the serendipitous discovery of hydrates of a previously unknown 1 : 1 co-crystal of caffeine and 4-hydroxybenzoic acid, and a known 1 : 1 co-crystal of piracetam and 4-hydroxybenzoic acid.

This article is part of the themed collection: Crystal engineering and crystallography in the pharmaceutical industry

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Article information

DOI: https://doi.org/10.1039/C2CE25080B
Article type: Communication
Submitted: 16 Jan 2012
Accepted: 31 Jan 2012
First published: 31 Jan 2012

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CrystEngComm, 2012,14, 2381-2385

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Co-crystals of caffeine and piracetam with 4-hydroxybenzoic acid: Unravelling the hidden hydrates of 1 : 1 co-crystals

S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2012, 14, 2381 DOI: 10.1039/C2CE25080B

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