Issue 42, 2012

Interactions of marine-derived γ-pyrone natural products with phospholipid membranes

Abstract

The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (3), and its proposed biosynthetic precursors (1 and 2) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates the observed data. The possibility that localised lipid domains within the membrane have an effect on the localisation is also addressed.

Graphical abstract: Interactions of marine-derived γ-pyrone natural products with phospholipid membranes

Supplementary files

Article information

Article type
Communication
Submitted
20 Aug 2012
Accepted
18 Sep 2012
First published
02 Oct 2012

Phys. Chem. Chem. Phys., 2012,14, 14489-14491

Interactions of marine-derived γ-pyrone natural products with phospholipid membranes

K. J. Powell, P. Sharma, J. L. Richens, B. M. Davis, J. E. Moses and P. O'Shea, Phys. Chem. Chem. Phys., 2012, 14, 14489 DOI: 10.1039/C2CP42920A

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