Issue 8, 2012
From the journal:

Green Chemistry

TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides†

Xiaobin Zhanga  and  Lei Wang*ab  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P.R. China

Abstract

A novel and efficient TBHP/I2-promoted oxidative coupling reaction of acetophenones with amines for the synthesis of α-ketoamides has been developed. The reactions proceeded smoothly at room temperature under metal-free and solvent-free conditions and generated the corresponding products in good yields.

Graphical abstract: TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides

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Article information

DOI
https://doi.org/10.1039/C2GC35489F
Article type
Communication
Submitted
02 Apr 2012
Accepted
25 May 2012
First published
28 May 2012

Green Chem., 2012,14, 2141-2145

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TBHP/I2-promoted oxidative coupling of acetophenones with amines at room temperature under metal-free and solvent-free conditions for the synthesis of α-ketoamides

X. Zhang and L. Wang, Green Chem., 2012, 14, 2141 DOI: 10.1039/C2GC35489F

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