Issue 2, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles†‡

Ping Li,a   Bo-Tao Teng,a   Fa-Gen Jin,a   Xin-Sheng Li,a   Wei-Dong Zhua  and  Jian-Wu Xie*a  

* Corresponding authors

a Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry and Life Science, Zhejiang Normal University, 321004 Jinhua, China
E-mail: xiejw@zjnu.cn
Fax: +86-579-82282610

Abstract

α,α-Dicyanoolefins react with hydroxylamine to afford 2,3-dihydroisoxazoles (2,3-dihydroisoxazoles can be easily isolated by filtration) in excellent yields under mild and environmentally benign conditions. A one-pot reaction in tandem with an unexpected ring-opening of 2,3-dihydroisoxazoles has been developed as well.

Graphical abstract: Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

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Article information

DOI
https://doi.org/10.1039/C1OB06318A
Article type
Communication
Submitted
03 Aug 2011
Accepted
27 Sep 2011
First published
27 Sep 2011

Org. Biomol. Chem., 2012,10, 244-247

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Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

P. Li, B. Teng, F. Jin, X. Li, W. Zhu and J. Xie, Org. Biomol. Chem., 2012, 10, 244 DOI: 10.1039/C1OB06318A

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