Issue 3, 2012
From the journal:

Organic & Biomolecular Chemistry

Enhanced reduction of C–N multiple bonds using sodium borohydride and an amorphous nickel catalyst†

Shouxin Liu,*ab   Yihua Yang,a   Xiaoli Zhen,a   Junzhang Li,a   Huimin He,a   Juan Fenga  and  Andrew Whiting*b  

* Corresponding authors

a State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, Hebei University of Science & Technology, Shijiazhuang, People's Republic of China
E-mail: shouxin.liu@durham.ac.uk

b Centre for Sustainable Chemical Processes, Department of Chemistry, Durham University, Science Laboratories, South Road, Durham, United Kingdom
E-mail: andy.whiting@durham.ac.uk
Fax: (t44)-191-386 1127

Abstract

Amorphous nickel powder (Ni0) was utilised as a catalyst under mild, aqueous, basic conditions for enhancing the sodium borohydride-mediated reduction of C–N multiple bonds such as oximes, imines, hydrazones and nitriles to produce the corresponding amines in good to excellent yields.

Graphical abstract: Enhanced reduction of C–N multiple bonds using sodium borohydride and an amorphous nickel catalyst

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Article information

DOI
https://doi.org/10.1039/C1OB06471A
Article type
Paper
Submitted
28 Aug 2011
Accepted
30 Sep 2011
First published
03 Oct 2011

Org. Biomol. Chem., 2012,10, 663-670

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Enhanced reduction of C–N multiple bonds using sodium borohydride and an amorphous nickel catalyst

S. Liu, Y. Yang, X. Zhen, J. Li, H. He, J. Feng and A. Whiting, Org. Biomol. Chem., 2012, 10, 663 DOI: 10.1039/C1OB06471A

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