Issue 6, 2012
From the journal:

Organic & Biomolecular Chemistry

Pd-Catalyzed asymmetric hydrogenation of 3-(toluenesulfonamidoalkyl)indoles†

Ying Duan,a   Mu-Wang Chen,a   Qing-An Chen,a   Chang-Bin Yua  and  Yong-Gui Zhou*a  

* Corresponding authors

a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, P. R. China
E-mail: ygzhou@dicp.ac.cn

Abstract

A series of 2-substituted 3-(toluenesulfonamidoalkyl)indoles was synthesized by application of (EtO)2POH or iodine as the catalyst, and was hydrogenated using chiral Pd catalyst, giving the 2,3-disubstituted indolines with up to 97% ee.

Graphical abstract: Pd-Catalyzed asymmetric hydrogenation of 3-(toluenesulfonamidoalkyl)indoles

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Article information

DOI
https://doi.org/10.1039/C1OB06777J
Article type
Paper
Submitted
23 Sep 2011
Accepted
03 Nov 2011
First published
17 Nov 2011

Org. Biomol. Chem., 2012,10, 1235-1238

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Pd-Catalyzed asymmetric hydrogenation of 3-(toluenesulfonamidoalkyl)indoles

Y. Duan, M. Chen, Q. Chen, C. Yu and Y. Zhou, Org. Biomol. Chem., 2012, 10, 1235 DOI: 10.1039/C1OB06777J

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