Issue 19, 2012
From the journal:

Organic & Biomolecular Chemistry

Single-step radiofluorination of peptides using continuous flow microreactor†

Svetlana V. Selivanova,a   Linjing Mu,a   Johanna Ungersboeck,b   Timo Stellfeld,c   Simon M. Ametamey,*a   Roger Schiblia  and  Wolfgang Wadsak*b  

* Corresponding authors

a Center for Radiopharmaceutical Sciences, ETH Zurich, IPW HCI H427, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
E-mail: simon.ametamey@pharma.ethz.ch
Fax: +41 44 633 1367
Tel: +41 44 633 7463

b Radiochemistry and Biomarker Development Unit, Department of Nuclear Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria
E-mail: wolfgang.wadsak@meduniwien.ac.at
Fax: +43 1 40400 1557
Tel: +43 1 40400 5255

c Bayer HealthCare, Global Drug Discovery, Berlin, Germany

Abstract

18F radiolabelling of peptides bearing two different prosthetic groups was successfully conducted in a continuous flow microfluidic device for the first time. Radiochemical yields were dependent on precursor concentration, reaction temperature and flow rate. The choice of leaving group had a dramatic influence on the reaction outcome. Rapid reaction optimization was possible.

Graphical abstract: Single-step radiofluorination of peptides using continuous flow microreactor

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Article information

DOI
https://doi.org/10.1039/C2OB00015F
Article type
Paper
Submitted
03 Jan 2012
Accepted
23 Mar 2012
First published
23 Mar 2012

Org. Biomol. Chem., 2012,10, 3871-3874

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Single-step radiofluorination of peptides using continuous flow microreactor

S. V. Selivanova, L. Mu, J. Ungersboeck, T. Stellfeld, S. M. Ametamey, R. Schibli and W. Wadsak, Org. Biomol. Chem., 2012, 10, 3871 DOI: 10.1039/C2OB00015F

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