Issue 10, 2012
From the journal:

Organic & Biomolecular Chemistry

Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives†

Akihiro Ohkubo,a   Yudai Nishino,a   Yu Ito,a   Hirosuke Tsunoda,a   Kohji Seioa  and  Mitsuo Sekine*a  

* Corresponding authors

a Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8501, Japan
E-mail: msekine@bio.titech.ac.jp
Fax: +81 45 924 5772
Tel: +81 45 924 5706

Abstract

In this paper, we report DNA and 2′-OMe-RNA probes containing 5-methyl-2-thiocytidine (m5s2C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group.

Graphical abstract: Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

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Article information

DOI
https://doi.org/10.1039/C2OB06641F
Article type
Paper
Submitted
27 Sep 2011
Accepted
06 Dec 2011
First published
07 Dec 2011

Org. Biomol. Chem., 2012,10, 2008-2010

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Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives

A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio and M. Sekine, Org. Biomol. Chem., 2012, 10, 2008 DOI: 10.1039/C2OB06641F

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