Issue 11, 2012
From the journal:

Organic & Biomolecular Chemistry

Interference of intrinsic curvature of DNA by DNA-intercalating agents†

Hong Kee Tan,a   Dawei Li,a   Robert Kenneth Gray,ab   Zhaoqi Yang,a   Magdeline Tao Tao Ng,a   Hao Zhang,a   Joel Ming Rui Tan,a   Shu Hui Hiew,a   Jasmine Yiqin Leea  and  Tianhu Li*a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371
E-mail: thli@ntu.edu.sg
Fax: +65 6791-1961
Tel: +65 6513-7364

b School of Chemistry, University of Edinburgh, King's Building, West Mains Road, Edinburgh, UK

Abstract

It has been demonstrated in our studies that the intrinsic curvature of DNA can be easily interrupted by low concentrations of chloroquine and ethidium bromide. In addition, the changes of DNA curvature caused by varying the concentration of these two DNA intercalators can be readily verified through using an atomic force microscope.

Graphical abstract: Interference of intrinsic curvature of DNA by DNA-intercalating agents

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Article information

DOI
https://doi.org/10.1039/C2OB06811G
Article type
Communication
Submitted
28 Oct 2011
Accepted
12 Jan 2012
First published
12 Jan 2012

Org. Biomol. Chem., 2012,10, 2227-2230

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Interference of intrinsic curvature of DNA by DNA-intercalating agents

H. K. Tan, D. Li, R. K. Gray, Z. Yang, M. T. T. Ng, H. Zhang, J. M. R. Tan, S. H. Hiew, J. Y. Lee and T. Li, Org. Biomol. Chem., 2012, 10, 2227 DOI: 10.1039/C2OB06811G

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