Issue 20, 2012

Simple chiral sulfonamideprimary amine catalysed highly enantioselective Michael addition of malonates to enones

Abstract

A chiral sulfonamide primary amine-organocatalysed, highly enantioselective Michael addition of malonates to enones has been developed. This reaction afforded the corresponding products in excellent yields (up to 99%) and excellent enantioselectivity (up to 99% ee).

Graphical abstract: Simple chiral sulfonamide primary amine catalysed highly enantioselective Michael addition of malonates to enones

Supplementary files

Article information

Article type
Paper
Submitted
29 Dec 2011
Accepted
22 Mar 2012
First published
23 Mar 2012

Org. Biomol. Chem., 2012,10, 4116-4123

Simple chiral sulfonamide primary amine catalysed highly enantioselective Michael addition of malonates to enones

C. Luo, Y. Jin and D. Du, Org. Biomol. Chem., 2012, 10, 4116 DOI: 10.1039/C2OB07191F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements