Issue 19, 2012
From the journal:

Organic & Biomolecular Chemistry

Copper(ii)-mediated oxidative cyclization of enamides to oxazoles†

Alison E. Wendlandta  and  Shannon S. Stahl*a  

* Corresponding authors

a Department of Chemistry, University of Wisconsin – Madison, 1101 University Ave, Madison, WI, USA
E-mail: stahl@chem.wisc.edu
Fax: +1 608 262 6143
Tel: +1 608 265 6288

Abstract

The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.

Graphical abstract: Copper(ii)-mediated oxidative cyclization of enamides to oxazoles

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Article information

DOI
https://doi.org/10.1039/C2OB25310K
Article type
Paper
Submitted
11 Feb 2012
Accepted
22 Mar 2012
First published
23 Mar 2012

Org. Biomol. Chem., 2012,10, 3866-3870

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Copper(II)-mediated oxidative cyclization of enamides to oxazoles

A. E. Wendlandt and S. S. Stahl, Org. Biomol. Chem., 2012, 10, 3866 DOI: 10.1039/C2OB25310K

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