Issue 20, 2012
From the journal:

Organic & Biomolecular Chemistry

Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling†

Timo Leermann,a   Pierre-Emmanuel Broutin,a   Frédéric R. Leroux*a  and  Françoise Colobert*a  

* Corresponding authors

a CNRS/Université de Strasbourg (ECPM), UMR 7509, 25 Rue Becquerel, F-67087 Strasbourg, France
E-mail: frederic.leroux@unistra.fr, francoise.colobert@unistra.fr
Fax: +33 (0)3 68 85 27 42
Tel: +33 (0)3 68 85 27 44

Abstract

An atropo-diastereoselective synthesis with dr up to 98/2 towards the biaryl subunit of vancomycin based on the use of enantiopure β-hydroxysulfoxide derivatives as novel chiral auxiliary is reported.

Graphical abstract: Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling

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Article information

DOI
https://doi.org/10.1039/C2OB25373A
Article type
Paper
Submitted
21 Feb 2012
Accepted
19 Mar 2012
First published
20 Mar 2012

Org. Biomol. Chem., 2012,10, 4095-4102

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Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki–Miyaura coupling

T. Leermann, P. Broutin, F. R. Leroux and F. Colobert, Org. Biomol. Chem., 2012, 10, 4095 DOI: 10.1039/C2OB25373A

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