Issue 36, 2012
From the journal:

Organic & Biomolecular Chemistry

From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives†

Maxim G. Uchuskin,a   Arkady S. Pilipenko,a   Olga V. Serdyuk,b   Igor V. Trushkovcd  and  Alexander V. Butin*ae  

* Corresponding authors

a Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University, Moskovskaya st. 2, Krasnodar, Russian Federation

b Department of Chemistry, Southern Federal University, Zorge 7, Rostov-on-Don, Russian Federation

c Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1-3, Moscow 119991, Russian Federation

d Laboratory of Chemical Synthesis, Federal RFesearch Center of Pediatric Hematology, Oncology and Immunology, Samora Mashel 1, Moscow, Russian Federation

e Perm State University, Bukireva 15, Perm, Russian Federation
E-mail: alexander_butin@mail.ru
Fax: (+7) 342-2371480

Abstract

Indolo[3,2-c]quinolines are pharmacologically attractive class of heterocyclic compounds. The method of their synthesis, based on transformation of furfural, which is a large-scale product of treatment of biomass including agricultural and forestry wastes, has been developed. This method was utilized for the total synthesis of antimalarial alkaloid isocryptolepine and its derivatives.

Graphical abstract: From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

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Article information

DOI
https://doi.org/10.1039/C2OB25836F
Article type
Communication
Submitted
01 May 2012
Accepted
06 Jul 2012
First published
09 Jul 2012

Org. Biomol. Chem., 2012,10, 7262-7265

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From biomass to medicines. A simple synthesis of indolo[3,2-c]quinolines, antimalarial alkaloid isocryptolepine, and its derivatives

M. G. Uchuskin, A. S. Pilipenko, O. V. Serdyuk, I. V. Trushkov and A. V. Butin, Org. Biomol. Chem., 2012, 10, 7262 DOI: 10.1039/C2OB25836F

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