Issue 38, 2012
From the journal:

Organic & Biomolecular Chemistry

Benzimidazole-based anion receptors exhibiting selectivity for lactate over pyruvate†

Jennifer R. Hiscock,a   Philip A. Gale,*a   Noémie Lalaoui,ab   Mark E. Lighta  and  Neil J. Wellsa  

* Corresponding authors

a Chemistry, University of Southampton, Southampton, UK
E-mail: philip.gale@soton.ac.uk
Fax: +44 (0)23 8059 3332
Tel: +44 (0)23 8059 6805

b Université Paris Descartes, CNRS UMR 8601, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, 45, rue des Saint-Pères, 75270 Paris Cedex 06, France

Abstract

The influence of anions on tautomerism in benzimidazole containing anion receptors has been studied via a variety of techniques in both solution and the solid state. The results show that hydrogen bonding interactions between the receptors and guests have a significant effect of the nature of the tautomer present. The compounds show a preference for complexation of lactate over pyruvate.

Graphical abstract: Benzimidazole-based anion receptors exhibiting selectivity for lactate over pyruvate

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Article information

DOI
https://doi.org/10.1039/C2OB26299A
Article type
Paper
Submitted
07 Jul 2012
Accepted
08 Aug 2012
First published
09 Aug 2012

Org. Biomol. Chem., 2012,10, 7780-7788

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Benzimidazole-based anion receptors exhibiting selectivity for lactate over pyruvate

J. R. Hiscock, P. A. Gale, N. Lalaoui, M. E. Light and N. J. Wells, Org. Biomol. Chem., 2012, 10, 7780 DOI: 10.1039/C2OB26299A

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