Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd2+ and Zn2+ in MeCN

Alexander Ciupa; Mary F. Mahon; Paul A. De Bank; Lorenzo Caggiano

doi:10.1039/C2OB26608C

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Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd²⁺ and Zn²⁺ in MeCN†

Alexander Ciupa,^a Mary F. Mahon,^b Paul A. De Bank*^a and Lorenzo Caggiano*^a

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* Corresponding authors

^a Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
E-mail: l.caggiano@bath.ac.uk
Fax: +44 (0)1225 386114
Tel: +44 (0)1225 385709

^b X-ray Crystallography Unit, Department of Chemistry, University of Bath, Claverton Down, Bath, UK

Abstract

An efficient two-step synthesis of pyrazoline ligand 1 is described which is an effective “turn on” fluorescent sensor for Cd²⁺ in MeCN. Oxidation to the corresponding pyrazole ligand 2 creates a “turn on” fluorescent sensor now selective for Zn²⁺ and able to distinguish it from Cd²⁺.

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Article information

DOI: https://doi.org/10.1039/C2OB26608C
Article type: Communication
Submitted: 14 Aug 2012
Accepted: 17 Sep 2012
First published: 18 Sep 2012

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Org. Biomol. Chem., 2012,10, 8753-8757

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Simple pyrazoline and pyrazole “turn on” fluorescent sensors selective for Cd²⁺ and Zn²⁺ in MeCN

A. Ciupa, M. F. Mahon, P. A. De Bank and L. Caggiano, Org. Biomol. Chem., 2012, 10, 8753 DOI: 10.1039/C2OB26608C

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Organic & Biomolecular Chemistry