Issue 3, 2012
From the journal:

RSC Advances

ZnO/Ag nanohybrid: synthesis, characterization, synergistic antibacterial activity and its mechanism†

Somnath Ghosh,a   V. S. Goudar,a   K. G. Padmalekha,b   S. V. Bhat,b   S. S. Indic  and  H. N. Vasan*a  

* Corresponding authors

a Solid State and Structural Chemistry Unit, Indian Institute of Science, C V Raman Avenue, Bangalore-560 012, India
E-mail: vasan@sscu.iisc.ernet.in
Fax: +91-80-23601310
Tel: +91-80-22933310

b Department of Physics, Indian Institute of Science, C V Raman Avenue, Bangalore-560 012, India

c Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore-560 012, India

Abstract

A highly homogeneous ZnO/Ag nanohybrid has been synthesized by a novel route, employing chitosan as mediator by purely electrostatic interaction. By employing various techniques such as powder XRD, UV-visible, IR spectroscopy and electron (SEM, TEM) microscopy, the formation of the nanohybrid has been established. The synergistic antibacterial effect of ZnO/Ag nanohybrid on Gram-positive and Gram-negative bacteria is found to be more effective, compared to the individual components (ZnO and Ag). Cytotoxicity experiments are carried out and the results are correlated to the solubility of the nanohybrid. A possible mechanism has been proposed for the antibacterial activity of ZnO/Ag nanohybrid, based on TEM studies on bacteria, carried out by employing the microtome technique and by EPR measurements on the hybrid.

Graphical abstract: ZnO/Ag nanohybrid: synthesis, characterization, synergistic antibacterial activity and its mechanism

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Article information

DOI
https://doi.org/10.1039/C1RA00815C
Article type
Paper
Submitted
29 Sep 2011
Accepted
04 Oct 2011
First published
28 Nov 2011

RSC Adv., 2012,2, 930-940

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ZnO/Ag nanohybrid: synthesis, characterization, synergistic antibacterial activity and its mechanism

S. Ghosh, V. S. Goudar, K. G. Padmalekha, S. V. Bhat, S. S. Indi and H. N. Vasan, RSC Adv., 2012, 2, 930 DOI: 10.1039/C1RA00815C

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