Issue 23, 2012
From the journal:

RSC Advances

Nanoparticle-mediated internalisation and release of a calcium channel blocker†

Cameron W. Evans,ab   Helena M. Viola,c   Diwei Ho,a   Livia C. Hool,c   Sarah A. Dunlop,b   Melinda Fitzgerald*b  and  K. Swaminathan Iyer*a  

* Corresponding authors

a School of Chemistry and Biochemistry, The University of Western Australia, Crawley WA 6009, Australia
E-mail: swaminatha.iyer@uwa.edu.au
Tel: +61 8 6488 4470

b Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Crawley WA 6009, Australia
E-mail: lindy.fitzgerald@uwa.edu.au
Tel: +61 8 6488 2353

c School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley WA 6009, Australia

Abstract

Lomerizine is a calcium channel blocker that selectively blocks L- and T-type Ca2+ channels, but it is effectively insoluble under physiological conditions. Herein we show that lomerizine can be released from a nanoparticle-based carrier by intracellular protonation in PC12 cells, suppressing Ca2+ influx in these cells in response to glutamate.

Graphical abstract: Nanoparticle-mediated internalisation and release of a calcium channel blocker

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2RA21058D
Article type
Communication
Submitted
28 May 2012
Accepted
20 Jul 2012
First published
25 Jul 2012

RSC Adv., 2012,2, 8587-8590

Permissions

Request permissions

Nanoparticle-mediated internalisation and release of a calcium channel blocker

C. W. Evans, H. M. Viola, D. Ho, L. C. Hool, S. A. Dunlop, M. Fitzgerald and K. S. Iyer, RSC Adv., 2012, 2, 8587 DOI: 10.1039/C2RA21058D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements