Issue 30, 2012
From the journal:

RSC Advances

First total synthesis of seimatopolide B†

U. Nookaraju,a   Anand Harbindu,a   Ankushkumar D. Bhise,a   Brijesh M. Sharmaa  and  Pradeep Kumar*a  

* Corresponding authors

a Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India
E-mail: pk.tripathi@ncl.res.in
Fax: +91–20–25902629
Tel: +91–20–25902050

Abstract

The first enantioselective total synthesis of seimatopolide B has been achieved, using ring-closing metathesis and DCC (N,N′-dicyclohexylcarbodiimide) coupling as key steps. The stereogenic centres were generated by means of iterative hydrolytic kinetic resolution (HKR) of racemic epoxides.

Graphical abstract: First total synthesis of seimatopolide B

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Article information

DOI
https://doi.org/10.1039/C2RA21838K
Article type
Communication
Submitted
16 Aug 2012
Accepted
24 Sep 2012
First published
15 Oct 2012

RSC Adv., 2012,2, 11231-11234

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First total synthesis of seimatopolide B

U. Nookaraju, A. Harbindu, A. D. Bhise, B. M. Sharma and P. Kumar, RSC Adv., 2012, 2, 11231 DOI: 10.1039/C2RA21838K

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