Molecular scaffolds with remote directing groups for selective palladium-catalyzed C–H bond functionalizations

Abstract

Palladium-catalyzed C–H bond functionalizations using novel directing groups are described. The chiral directing group enables reactivity with high levels of site-specificity, achieving chemoselective, regioselective, and diastereoselective oxidations. The directing groups also feature aminal components, which allow in situ transacetalization and offer the potential for catalytic turnover of the organic frameworks. An X-ray crystal structure of a cyclometallated complex also provides information about the nature of the directing group.