Issue 25, 2012
From the journal:

Soft Matter

A peptide-based material for therapeutic carbon monoxide delivery†

John B. Matson,‡a   Matthew J. Webber,‡b   Vibha K. Tamboli,c   Benjamin Webera  and  Samuel I. Stupp*ade  

* Corresponding authors

a Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL, USA
E-mail: s-stupp@northwestern.edu
Fax: +1 312 503-2482
Tel: +1 312 503-6713

b Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA

c Master of Biotechnology Program, Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA

d Departments of Chemistry and Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA

e Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA

Abstract

We report on the preparation of the first material for therapeutic delivery of CO. A peptide amphiphile was synthesized with a covalently attached ruthenium tricarbonyl. Self-assembled nanofiber gels containing this peptide spontaneously released CO with prolonged release kinetics compared to soluble CO donors. Oxidatively stressed cardiomyocytes had improved viability when treated with this peptide, demonstrating its potential as a biodegradable gel for localized therapeutic CO delivery.

Graphical abstract: A peptide-based material for therapeutic carbon monoxide delivery

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Article information

DOI
https://doi.org/10.1039/C2SM25785H
Article type
Communication
Submitted
03 Apr 2012
Accepted
09 May 2012
First published
24 May 2012

Soft Matter, 2012,8, 6689-6692

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A peptide-based material for therapeutic carbon monoxide delivery

J. B. Matson, M. J. Webber, V. K. Tamboli, B. Weber and S. I. Stupp, Soft Matter, 2012, 8, 6689 DOI: 10.1039/C2SM25785H

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