Issue 3, 2013
From the journal:

Analyst

Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues†

Bifeng Chen,a   Wei Li,b   Cong Lv,a   Manman Zhao,b   Hongwei Jin,a   Hongfang Jin,b   Junbao Du,b   Liangren Zhanga  and  Xinjing Tang*a  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Rd, Beijing 100191, China
E-mail: xinjingt@bjmu.edu.cn
Fax: +86-10-82805635
Tel: +86-10-82805635

b Department of Pediatrics, Peking University First Hospital, No. 1 Xi-An Men Street, West District, Beijing, China

Abstract

A coumarin-based fluorescence chemoprobe was developed and evaluated for the selective and sensitive detection of hydrogen sulfide in degassed PBS buffers and fetal bovine serum. Fluorescence detection of hydrogen sulfide in living cells was also successfully achieved using two-photon confocal fluorescence imaging. Further in situ visualization of endogenous H2S was realized in cardiac tissues of normal rats and atherosclerosis (AS) rats.

Graphical abstract: Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues

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Article information

DOI
https://doi.org/10.1039/C2AN36113B
Article type
Paper
Submitted
13 Aug 2012
Accepted
30 Nov 2012
First published
30 Nov 2012

Analyst, 2013,138, 946-951

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Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues

B. Chen, W. Li, C. Lv, M. Zhao, H. Jin, H. Jin, J. Du, L. Zhang and X. Tang, Analyst, 2013, 138, 946 DOI: 10.1039/C2AN36113B

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