Issue 8, 2013

Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

Abstract

Real-time image guidance in the operating room is needed to improve instantaneous surgical decisions. Toward this goal, we utilized a new fluorescence goggle system and a near-infrared fluorescent dye approved for human use, indocyanine green, to demonstrate the feasibility of detecting liver tumors intraoperatively. The fluorescence goggle provided successful imaging of multifocal breast cancer metastases in mouse liver. Diffused tumor deposits as small as 0.8 mm in diameter were detected, which were not obvious without the fluorescence goggle. A combination of surface-weighted fluorescence imaging and deep tissue-sensitive ultrasound imaging allowed comprehensive image guidance with the fluorescence goggle system for tumor resection in a rabbit VX2 liver metastasis model. This multimodal detection and guided surgical intervention strategy using ultrasonic imaging and real-time intraoperative fluorescence guidance is a promising and innovative technology platform for improving surgical outcome of human patients with primary or metastatic liver cancer.

Graphical abstract: Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

Supplementary files

Article information

Article type
Communication
Submitted
22 Jan 2013
Accepted
25 Feb 2013
First published
25 Feb 2013

Analyst, 2013,138, 2254-2257

Intraoperative detection of liver tumors aided by a fluorescence goggle system and multimodal imaging

Y. Liu, W. J. Akers, A. Q. Bauer, S. Mondal, K. Gullicksrud, G. P. Sudlow, J. P. Culver and S. Achilefu, Analyst, 2013, 138, 2254 DOI: 10.1039/C3AN00165B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements