Issue 17, 2013
From the journal:

Analyst

Functionalized liposome purificationvia Liposome Extruder Purification (LEP)†

Nathan J. Alves,a   William Cusick,a   Jared F. Stefanick,a   Jonathan D. Ashley,a   Michael W. Handlogtena  and  Basar Bilgicer*abc  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Notre Dame, 165 Fitzpatrick Hall, Notre Dame, IN 46556-5637, USA
E-mail: bbilgicer@nd.edu
Fax: +1-574-631-8366
Tel: +1-574-631-1429

b Advanced Diagnostics and Therapeutics, University of Notre Dame, Notre Dame, IN 46556, USA

c Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA

Abstract

Liposome Extruder Purification (LEP) allows for the rapid purification of diverse liposome formulations using the same extrusion apparatus employed during liposome formation. The LEP process provides a means for purifying functionalized liposomes from non-conjugated drug or protein contaminants with >93% liposome recovery and >93% contaminant removal in a single step.

Graphical abstract: Functionalized liposome purification via Liposome Extruder Purification (LEP)

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Article information

DOI
https://doi.org/10.1039/C3AN00680H
Article type
Communication
Submitted
05 Apr 2013
Accepted
02 Jul 2013
First published
02 Jul 2013

Analyst, 2013,138, 4746-4751

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Functionalized liposome purification via Liposome Extruder Purification (LEP)

N. J. Alves, W. Cusick, J. F. Stefanick, J. D. Ashley, M. W. Handlogten and B. Bilgicer, Analyst, 2013, 138, 4746 DOI: 10.1039/C3AN00680H

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