Issue 7, 2013
From the journal:

Analyst

A novel near-infrared fluorescent probe for selectively sensing nitroreductase (NTR) in an aqueous medium†

Youmin Shi,a   Sichun Zhang*a  and  Xinrong Zhang*a  

* Corresponding authors

a Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Tsinghua University, Beijing, P.R. China
E-mail: xrzhang@tsinghua.edu.cn, sczhang@tsinghua.edu.cn
Tel: +86 (010) 62787678

Abstract

A novel near-infrared (NIR) fluorescent probe based on cyanine dyes was designed and synthesized to detect nitroreductase (NTR) activity. Upon reaction with NTR, the nitro-group of p-nitrobenzyl moiety was reduced to amino-group and therefore renews the π-electron conjugation of the dye, resulting in the intense NIR fluorescent emission (708 nm). This redox-induced NIR-fluorescence probe has been successfully applied to the detection of NTR activity under physiological conditions with high selectivity.

Graphical abstract: A novel near-infrared fluorescent probe for selectively sensing nitroreductase (NTR) in an aqueous medium

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Article information

DOI
https://doi.org/10.1039/C3AN36807F
Article type
Communication
Submitted
05 Dec 2012
Accepted
04 Feb 2013
First published
04 Feb 2013

Analyst, 2013,138, 1952-1955

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A novel near-infrared fluorescent probe for selectively sensing nitroreductase (NTR) in an aqueous medium

Y. Shi, S. Zhang and X. Zhang, Analyst, 2013, 138, 1952 DOI: 10.1039/C3AN36807F

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