High specific phosphopeptides enrichment by titanium silicalite with post-treatment of desilication

Bo Xu; Chen Chen; Fangjun Wang; Yangyang Bian; Kai Cheng; Hongqiang Qin; Chunxia Song; Jun Zhu; Jing Liu; Mingliang Ye; Hanfa Zou

doi:10.1039/C3AY00064H

High specific phosphopeptides enrichment by titanium silicalite with post-treatment of desilication†

Bo Xu,^a Chen Chen,^b Fangjun Wang,*^a Yangyang Bian,^a Kai Cheng,^a Hongqiang Qin,^a Chunxia Song,^a Jun Zhu,^a Jing Liu,^a Mingliang Ye^a and Hanfa Zou*^a

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* Corresponding authors

^a CAS Key Laboratory of Separation Science for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
E-mail: wangfj@dicp.ac.cn, hanfazou@dicp.ac.cn

^b State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Abstract

The titanium silicalite-1 (TS-1) with post-treatment of chemical selective desilication (T-TS-1) has been synthesized, characterized and applied as a potential adsorbent for selective capture of phosphopeptides from complex biological samples prior to mass spectrometry analysis. A T-TS-1 material-based successive phosphopeptide enrichment strategy has also been established for real biological sample analysis, which exhibited high enrichment selectivity and is comparable to existing materials.

Analytical Methods

High specific phosphopeptides enrichment by titanium silicalite with post-treatment of desilication†

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High specific phosphopeptides enrichment by titanium silicalite with post-treatment of desilication

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