Issue 4, 2013
From the journal:

Chemical Communications

Controlling the function of DNA nanostructures with specific trigger sequences†

Stijn Deborggraeve,abcd   Jian Yuan Dai,ab   Yi Xiao*ab  and  Hyongsok Tom Soh*ab  

* Corresponding authors

a Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA
E-mail: yixiao@physics.ucsb.edu, tsoh@engr.ucsb.edu
Fax: +1 805 8938651
Tel: +1 805 8937985

b Materials Department, University of California, Santa Barbara, USA

c Biomedical Sciences Department, Institute of Tropical Medicine, 2000 Antwerpen, Belgium

d Rega Institute, KU Leuven, 3000 Leuven, Belgium

Abstract

We report a hybridization-based switching mechanism with single-base specificity that can be readily integrated with functional DNA nanostructures. As an exemplar, we have developed a switchable DNAzyme (SDZ) that only becomes activated in the presence of a perfectly matched trigger sequence and operates effectively at room temperature.

Graphical abstract: Controlling the function of DNA nanostructures with specific trigger sequences

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Article information

DOI
https://doi.org/10.1039/C2CC36878A
Article type
Communication
Submitted
21 Sep 2012
Accepted
13 Nov 2012
First published
28 Nov 2012

Chem. Commun., 2013,49, 397-399

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Controlling the function of DNA nanostructures with specific trigger sequences

S. Deborggraeve, J. Y. Dai, Y. Xiao and H. T. Soh, Chem. Commun., 2013, 49, 397 DOI: 10.1039/C2CC36878A

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