Issue 6, 2013
From the journal:

Chemical Communications

Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68†

Bradley P. Waldron,a   David Parker,*a   Carsten Burchardt,b   Dmitry S. Yufit,a   Melanie Zimnyb  and  Frank Roeschb  

* Corresponding authors

a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@dur.ac.uk
Fax: +44 (0)191-3844737
Tel: +44 (0)191-3342033

b Institute of Nuclear Chemistry, University of Mainz, Fritz-Strassmann-Weg 2, 55128 Mainz, Germany

Abstract

Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind 68Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.

Graphical abstract: Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

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Article information

DOI
https://doi.org/10.1039/C2CC37544C
Article type
Communication
Submitted
16 Oct 2012
Accepted
13 Nov 2012
First published
14 Nov 2012

Chem. Commun., 2013,49, 579-581

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Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

B. P. Waldron, D. Parker, C. Burchardt, D. S. Yufit, M. Zimny and F. Roesch, Chem. Commun., 2013, 49, 579 DOI: 10.1039/C2CC37544C

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