Issue 14, 2013
From the journal:

Chemical Communications

Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles†

Xiao-Feng Xia,a   Lu-Lu Zhang,a   Xian-Rong Song,a   Yan-Ning Niu,a   Xue-Yuan Liua  and  Yong-Min Liang*ab  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China

b State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, P. R. China
E-mail: liangym@lzu.edu.cn

Abstract

A new and efficient catalytic approach to the synthesis of 3-acylindoles under Pd–Cu-cocatalyzed oxidative conditions is demonstrated. tert-Butyl hydroperoxide (TBHP) acts not only as the oxidant, but also as an oxygen source in the approach. The process allows quick and atom-economical assembly of 3-acylindoles from readily available starting materials and tolerates a broad range of functional groups.

Graphical abstract: Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles

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Article information

DOI
https://doi.org/10.1039/C2CC37805A
Article type
Communication
Submitted
27 Oct 2012
Accepted
20 Dec 2012
First published
03 Jan 2013

Chem. Commun., 2013,49, 1410-1412

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Palladium–copper-cocatalyzed intramolecular oxidative coupling: an efficient and atom-economical strategy for the synthesis of 3-acylindoles

X. Xia, L. Zhang, X. Song, Y. Niu, X. Liu and Y. Liang, Chem. Commun., 2013, 49, 1410 DOI: 10.1039/C2CC37805A

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