Issue 7, 2013
From the journal:

Chemical Communications

Remarkable photocytotoxicity of a novel triazole-linked cationic porphyrin–β-carboline conjugate†

Dalip Kumar,*a   Bhupendra A. Mishra,a   K. P. Chandra Shekar,a   Anil Kumar,a   Kanako Akamatsu,b   Eriko Kusakab  and  Takeo Ito*b  

* Corresponding authors

a Department of Chemistry, Birla Institute of Technology & Science, Pilani-333 031, India
E-mail: dalipk@bits–pilani.ac.in

b Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
E-mail: takeoit@scl.kyoto–u.ac.jp

Abstract

Employing a click chemistry approach we have synthesized a novel triazole-linked cationic porphyrin–β-carboline conjugate which exhibited remarkable photocytotoxicity against the A549 cancer cell line (IC50 = 60 nM).

Graphical abstract: Remarkable photocytotoxicity of a novel triazole-linked cationic porphyrin–β-carboline conjugate

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Article information

DOI
https://doi.org/10.1039/C2CC38018H
Article type
Communication
Submitted
06 Nov 2012
Accepted
26 Nov 2012
First published
27 Nov 2012

Chem. Commun., 2013,49, 683-685

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Remarkable photocytotoxicity of a novel triazole-linked cationic porphyrin–β-carboline conjugate

D. Kumar, B. A. Mishra, K. P. Chandra Shekar, A. Kumar, K. Akamatsu, E. Kusaka and T. Ito, Chem. Commun., 2013, 49, 683 DOI: 10.1039/C2CC38018H

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