Issue 14, 2013
From the journal:

Chemical Communications

Gold-mediated selective cysteine modification of peptides using allenes†

Anna On-Yee Chan,a   Johnson Lui-Lui Tsai,a   Vanessa Kar-Yan Lo,a   Gai-Li Li,b   Man-Kin Wong*b  and  Chi-Ming Che*a  

* Corresponding authors

a State Key Laboratory of Synthetic Chemistry, Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: +852-2857-1586

b Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China
E-mail: bcmkwong@polyu.edu.hk
Fax: +852-2364-9932

Abstract

A new approach for selective modification of cysteine-containing peptides through gold-mediated oxidative allene–thiol coupling reaction in aqueous medium is developed.

Graphical abstract: Gold-mediated selective cysteine modification of peptides using allenes

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Article information

DOI
https://doi.org/10.1039/C2CC38214H
Article type
Communication
Submitted
14 Nov 2012
Accepted
24 Dec 2012
First published
16 Jan 2013

Chem. Commun., 2013,49, 1428-1430

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Gold-mediated selective cysteine modification of peptides using allenes

A. On-Yee Chan, J. Lui-Lui Tsai, V. Kar-Yan Lo, G. Li, M. Wong and C. Che, Chem. Commun., 2013, 49, 1428 DOI: 10.1039/C2CC38214H

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