Issue 25, 2013
From the journal:

Chemical Communications

Protein corona significantly reduces active targeting yield†

Vahid Mirshafiee,a   Morteza Mahmoudi,bc   Kaiyan Lou,‡a   Jianjun Chengd  and  Mary L. Kraft*ab  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA
E-mail: mlkraft@illinois.edu

b Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

c Department of Nanotechnology, and Nanotechnology Research Center, Faculty of Pharmaceutics, Tehran University of Medical Sciences, Tehran, Iran

d Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Abstract

When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands.

Graphical abstract: Protein corona significantly reduces active targeting yield

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Article information

DOI
https://doi.org/10.1039/C3CC37307J
Article type
Communication
Submitted
06 Oct 2012
Accepted
11 Feb 2013
First published
12 Feb 2013

Chem. Commun., 2013,49, 2557-2559

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Protein corona significantly reduces active targeting yield

V. Mirshafiee, M. Mahmoudi, K. Lou, J. Cheng and M. L. Kraft, Chem. Commun., 2013, 49, 2557 DOI: 10.1039/C3CC37307J

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