No-carrier-added [18F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [18F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[18F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel 18F-labeling synthons and PET radiotracers.
![Graphical abstract: No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C3CC37795D&imageInfo.ImageIdentifier.Year=2013)
J. Chun, C. L. Morse, F. T. Chin and V. W. Pike, Chem. Commun., 2013, 49, 2151 DOI: 10.1039/C3CC37795D
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