Issue 25, 2013
From the journal:

Chemical Communications

X-ray triggered release of doxorubicin from nanoparticledrug carriers for cancer therapy†

Zane B. Starkewolf,a   Larissa Miyachi,a   Joyce Wonga  and  Ting Guo*a  

* Corresponding authors

a Department of Chemistry, University of California, One Shields Ave., Davis, CA 95616, USA
E-mail: tguo@ucdavis.edu
Fax: +1 530 752-8995
Tel: +1 530 754-5283

Abstract

Enhanced cellular toxicity was observed using X-ray irradiated nanoparticle drug carriers (NDC) consisting of doxorubicin (DOX) conjugated to DNA strands attached to the surface of gold nanoparticles. Kinetic studies showed that X-rays, acting as a triggering modality, generated reactive oxygen species to break DNA strands and release DOX.

Graphical abstract: X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy

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Article information

DOI
https://doi.org/10.1039/C3CC38100E
Article type
Communication
Submitted
09 Nov 2012
Accepted
06 Feb 2013
First published
20 Feb 2013

Chem. Commun., 2013,49, 2545-2547

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X-ray triggered release of doxorubicin from nanoparticle drug carriers for cancer therapy

Z. B. Starkewolf, L. Miyachi, J. Wong and T. Guo, Chem. Commun., 2013, 49, 2545 DOI: 10.1039/C3CC38100E

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