Issue 31, 2013
From the journal:

Chemical Communications

Hydrophobic end-gated silica nanotubes for intracellular glutathione-stimulated drug delivery in drug-resistant cancer cells†

Lulu Wang,a   Mira Kim,b   Qiling Fang,a   Junhong Min,c   Won Il Jeon,d   So Yeong Lee,d   Sang Jun Son,*a   Sang-Woo Joo*b  and  Sang Bok Lee*ef  

* Corresponding authors

a Department of Chemistry, Gachon University, Seongnam, Korea
E-mail: sjson@gachon.ac.kr

b Department of Chemistry, Soongsil University, Seoul 156-743, Korea
E-mail: sjoo@ssu.ac.kr

c School of Integrative Engineering, Chung-Ang University, Seoul 156-756, Korea

d Laboratory of Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea

e Department of Chemistry & Biochemistry, University of Maryland, College Park, Maryland 20742, USA
E-mail: slee@umd.edu

f Graduate School of Nanoscience and Technology (WCU), Korea Advance Institute of Science and Technology, Daejeon 305-701, Korea

Abstract

Intracellular glutathione-triggered doxorubicin release from silica nanotubes with hydrophobic labile cap was demonstrated for the drug-resistant cancer cell treatment.

Graphical abstract: Hydrophobic end-gated silica nanotubes for intracellular glutathione-stimulated drug delivery in drug-resistant cancer cells

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Article information

DOI
https://doi.org/10.1039/C3CC38761E
Article type
Communication
Submitted
06 Dec 2012
Accepted
06 Feb 2013
First published
06 Feb 2013

Chem. Commun., 2013,49, 3194-3196

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Hydrophobic end-gated silica nanotubes for intracellular glutathione-stimulated drug delivery in drug-resistant cancer cells

L. Wang, M. Kim, Q. Fang, J. Min, W. I. Jeon, S. Y. Lee, S. J. Son, S. Joo and S. B. Lee, Chem. Commun., 2013, 49, 3194 DOI: 10.1039/C3CC38761E

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